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DAO uses copper as a cofactor and requires vitamin B6 (in its P5P form) to function optimally. 24 Multiple SNPs in AOC1 have been associated with significantly reduced DAO activity and histamine intolerance

Summary: Vitamin B12 treatment typically begins producing early haematological responses within 34 days, with neurological symptoms starting to improve within 12 weeks, though complete symptom resolution may require several weeks to months depending on deficiency severity and treatment route

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The molecule is universally present in living cells as a cofactor for hundreds of enzymes mediating redox reactions in central metabolism